Key Words: Fuzzy sets theory; random search with back step; combined algorithm; initial condition.
Abstract. A combined algorithm for optimisation of biotechnological processes has been developed. The algorithm includes a random search method for an optimal choice of an initial point and a method based of the fuzzy sets theory. Combining both methods overcomes а major disadvantage of the fuzzy optimisation method, connected with a determination of large scale problems. The combined algorithm has been successfully applied for optimisation of the initial condition and optimal control of the biotransformation process of whey fermentation by а strain Kluyveromyces lactis MC5.